2′-Hydroxyacetophenone CAS 118-93-4 | Light-Yellow Oily Liquid ≤0.5 % Moisture – Pharmaceutical & Flavor Grade

Short Description:

2′-Hydroxyacetophenone (CAS 118-93-4) is an aromatic ketone bearing an ortho-hydroxyl group that enables unique chelation, UV-absorption and reactivity profiles. Supplied as a light-yellow oily liquid with moisture capped at 0.5 % max, it serves as a critical intermediate for APIs, fragrance molecules, UV-blockers and specialty polymers. Our plant adopts vacuum fractional distillation plus multi-stage filtration to reach chromatographic purities >99 % while keeping color low. Whether you need kilo-lab quantities or multi-ton campaigns, we provide scalable, regulation-ready supply.

 

 

 


Product Detail

Product Tags

Product introduction:

2′-Hydroxyacetophenone (also known as o-Hydroxyacetophenone or ortho-Hydroxyacetophenone) is a versatile aromatic ketone with a hydroxyl group at the ortho position. With the CAS Number 118-93-4, this compound appears as a light yellow oily liquid and features a moisture content of 0.5% Max, ensuring its stability and suitability for various precision chemical applications.

Known for its role as an essential building block in pharmaceuticals, agrochemicals, fragrances, and dye manufacturing, 2′-Hydroxyacetophenone combines aromatic reactivity with functional group versatility. Its moderate polarity and active hydroxyl group allow it to engage in hydrogen bonding, acylation, and alkylation reactions—making it highly valued in both research and industrial production.

Property Specification
Product Name 2′-Hydroxyacetophenone
Synonyms o-Hydroxyacetophenone, ortho-Hydroxyacetophenone
CAS Number 118-93-4
Molecular Formula C8H8O2
Molecular Weight 136.15 g/mol
Appearance Light yellow oily liquid
Purity (GC) ≥99.0%
Moisture Content (KF) ≤0.50%
Boiling Point 238 °C
Melting Point ~4 °C
Density (20°C) ~1.16 g/cm³
Refractive Index (n20/D) 1.560–1.564
Flash Point 118 °C (Closed Cup)
Packaging Options 1kg, 5kg, 25kg drum or custom size

 COA

Parameter Specification Method Typical Result
Appearance Light-yellow oily liquid Visual Pass
Purity (GC) ≥99.0 % GC-FID 99.5 %
Moisture ≤0.5 % Karl-Fischer 0.18 %
Color (Gardner) ≤3 ASTM D1544 1.8
Refractive Index (20 °C) 1.535 – 1.540 ASTM D1218 1.537
Density (25 °C) 1.130 – 1.135 g cm⁻³ ASTM D4052 1.132 g cm⁻³
Heavy Metals (Pb) ≤10 ppm ICP-MS <1 ppm
Shelf Life 24 months

Applications of 2′-Hydroxyacetophenone

2′-Hydroxyacetophenone is widely used across multiple industries due to its chemical versatility and high reactivity. Below are the most common application domains:

Pharmaceutical Intermediates

Precursor in the synthesis of anti-inflammatory, antibacterial, and antifungal drugs.

Frequently used in the development of benzodiazepine and flavonoid derivatives.

Ideal for creating hydroxylated and halogenated aromatic compounds in medicinal chemistry.

Agrochemicals

Serves as an intermediate in the synthesis of herbicides and plant growth regulators.

Enhances the bioactivity and stability of fluorinated or phenolic pesticides.

Fragrance and Flavors

Used to manufacture aroma chemicals with sweet, almond-like, or balsamic notes.

Acts as a blending ingredient in high-end perfumes and flavors.

Polymer and Dye Industry

Precursor for azo dyes and reactive dyes used in textile finishing.

Improves solubility and binding capacity in polymer synthesis.

 

 


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