Product introduction:
2′-Hydroxyacetophenone (also known as o-Hydroxyacetophenone or ortho-Hydroxyacetophenone) is a versatile aromatic ketone with a hydroxyl group at the ortho position. With the CAS Number 118-93-4, this compound appears as a light yellow oily liquid and features a moisture content of 0.5% Max, ensuring its stability and suitability for various precision chemical applications.
Known for its role as an essential building block in pharmaceuticals, agrochemicals, fragrances, and dye manufacturing, 2′-Hydroxyacetophenone combines aromatic reactivity with functional group versatility. Its moderate polarity and active hydroxyl group allow it to engage in hydrogen bonding, acylation, and alkylation reactions—making it highly valued in both research and industrial production.
Property | Specification |
Product Name | 2′-Hydroxyacetophenone |
Synonyms | o-Hydroxyacetophenone, ortho-Hydroxyacetophenone |
CAS Number | 118-93-4 |
Molecular Formula | C8H8O2 |
Molecular Weight | 136.15 g/mol |
Appearance | Light yellow oily liquid |
Purity (GC) | ≥99.0% |
Moisture Content (KF) | ≤0.50% |
Boiling Point | 238 °C |
Melting Point | ~4 °C |
Density (20°C) | ~1.16 g/cm³ |
Refractive Index (n20/D) | 1.560–1.564 |
Flash Point | 118 °C (Closed Cup) |
Packaging Options | 1kg, 5kg, 25kg drum or custom size |
COA
Parameter | Specification | Method | Typical Result |
Appearance | Light-yellow oily liquid | Visual | Pass |
Purity (GC) | ≥99.0 % | GC-FID | 99.5 % |
Moisture | ≤0.5 % | Karl-Fischer | 0.18 % |
Color (Gardner) | ≤3 | ASTM D1544 | 1.8 |
Refractive Index (20 °C) | 1.535 – 1.540 | ASTM D1218 | 1.537 |
Density (25 °C) | 1.130 – 1.135 g cm⁻³ | ASTM D4052 | 1.132 g cm⁻³ |
Heavy Metals (Pb) | ≤10 ppm | ICP-MS | <1 ppm |
Shelf Life | 24 months | — | — |
Applications of 2′-Hydroxyacetophenone
2′-Hydroxyacetophenone is widely used across multiple industries due to its chemical versatility and high reactivity. Below are the most common application domains:
Pharmaceutical Intermediates
Precursor in the synthesis of anti-inflammatory, antibacterial, and antifungal drugs.
Frequently used in the development of benzodiazepine and flavonoid derivatives.
Ideal for creating hydroxylated and halogenated aromatic compounds in medicinal chemistry.
Agrochemicals
Serves as an intermediate in the synthesis of herbicides and plant growth regulators.
Enhances the bioactivity and stability of fluorinated or phenolic pesticides.
Fragrance and Flavors
Used to manufacture aroma chemicals with sweet, almond-like, or balsamic notes.
Acts as a blending ingredient in high-end perfumes and flavors.
Polymer and Dye Industry
Precursor for azo dyes and reactive dyes used in textile finishing.
Improves solubility and binding capacity in polymer synthesis.
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