3-Fluoro-4-methoxyacetophenone (CAS 455-91-4) | ≥99.0 % White-to-Off-White Powder for Precision Synthesis & API Advancement

3-Fluoro-4-methoxyacetophenone (CAS 455-91-4) | ≥99.0 % White-to-Off-White Powder for Precision Synthesis & API Advancement Featured Image
  • 3-Fluoro-4-methoxyacetophenone (CAS 455-91-4) | ≥99.0 % White-to-Off-White Powder for Precision Synthesis & API Advancement

Short Description:

Fluoro-4-methoxyacetophenone, referenced under CAS 455-91-4, is a white-to-off-white crystalline powder with ≥99.0 % GC purity. The strategic placement of a fluorine atom ortho to the carbonyl and a para-methoxy group delivers enhanced electrophilicity, metabolic stability, and lipophilic balance, making this ketone a high-value scaffold for fluorinated APIs, agrochemical discovery, and OLED material research. Each lot is micronized to ≤100 µm to improve flowability and dissolution kinetics, while double-lined PE bags inside aluminum foil pouches guarantee moisture protection and extended shelf life.


Product Detail

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Product introduction

3-Fluoro-4-methoxyacetophenone is a high-purity aromatic ketone compound featuring a fluorine atom at the meta position and a methoxy group at the para position of the benzene ring. This unique molecular arrangement gives it distinct physical and chemical properties, making it valuable for pharmaceutical synthesis, fine chemicals production, and research applications.

Supplied in the form of a white or off-white crystalline powder, our 3-Fluoro-4-methoxyacetophenone is manufactured to meet ≥99.0% purity standards, ensuring low impurity levels, consistent quality, and excellent performance in demanding industrial and laboratory processes.

Item Specification
Product Name 3-Fluoro-4-methoxyacetophenone
CAS Number 455-91-4
Appearance White or off-white powder
Purity ≥ 99.0%
Molecular Formula C<sub>9</sub>H<sub>9</sub>FO<sub>2</sub>
Molecular Weight 168.17 g/mol
Melting Point 46 – 48°C
Boiling Point Approx. 280°C
Storage Store in a cool, dry, and well-ventilated environment
Packaging Sealed bags, drums, or customized packaging options

COA

Property Specification Test Method Competitive Advantage
Chemical Name 3-Fluoro-4-methoxyacetophenone IUPAC Exact regio-isomer, no positional contaminants
CAS Number 455-91-4 CAS Registry Globally searchable identifier
Appearance White to off-white powder Visual @ 25 °C Color consistency simplifies QC
Purity (GC) ≥99.0 % GC-FID Redimes work-up & boosts yields
Moisture (KF) ≤0.3 % Karl Fischer Inhibits hydrolysis & color drift
Melting Point 72–75 °C DSC Sharp range confirms purity
Molecular Formula C₉H₉FO₂ Elemental analysis Matches stoichiometry for scale-up
Molecular Weight 168.17 g mol⁻¹ Calculated Precise molar dosing
Particle Size D90 ≤100 µm Laser diffraction Fast dissolution, ideal for flow reactors
Loss on Drying ≤0.5 % USP <731> Minimal volatile residues
Residue on Ignition ≤0.1 % USP <281> Low ash for electronic applications
Heavy Metals ≤10 ppm total ICP-MS Meets USP/EP elemental impurities

 

Applications of 3-fluoro-4-methoxyacetophenone

3-Fluoro-4-methoxyacetophenone is an important intermediate with a wide range of applications in various industries:

 Pharmaceutical Industry: It is a key component in the synthesis of active pharmaceutical ingredients (APIs) and pharmaceutical intermediates, including JAK/STAT inhibitors and SGLT-2 modulators.

 Fine Chemical Manufacturing: These compounds are used to produce specialty chemicals with specific functional properties that enhance the performance of various products.

 Agrochemical Synthesis: It plays a role in the development of crop protection agents and agrochemical intermediates, including the building blocks of SDHI fungicides.

Research and Development: 3-Fluoro-4-methoxyacetophenone is used for laboratory-scale synthesis and for research in organic chemistry and materials science, promoting advances in these fields.

OLED Materials: It is used as an electron transport layer (ETL) dopant in organic light-emitting diodes (OLEDs), improving device efficiency.

Radiochemistry: This compound serves as a precursor to the [¹⁸F]PET tracer, essential for positron emission tomography imaging.

Custom Synthesis: It also involves custom synthesis applications, including Grignard reactions and Suzuki coupling reactions, enabling the creation of complex organic molecules.

 

 

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