4-Chloroacetophenone |CAS 99-91-2 | High-Purity 99%|Premium Intermediate for Pharmaceutical

Short Description:

4-Chloroacetophenone is a halogen-substituted aromatic ketone with a chlorine atom located at the para-position on the phenyl ring. This structure combines the chemical reactivity of the acetophenone group with the electrophilic nature of the chlorine atom, making it a highly adaptable intermediate for downstream chemical synthesis.

Its excellent thermal stability, moderate polarity, and strong electron-withdrawing effects contribute to its widespread industrial utility and synthetic versatility.

Purity ≥99.0%: Ensures superior performance in sensitive synthesis and formulations

Low Moisture Content (≤0.20%): Minimizes risk in moisture-sensitive processes

Dual Physical Form: Easy to handle as liquid or crystalline solid depending on temperature

Excellent Stability: Stable under standard storage and transport conditions

Wide Industrial Compatibility: Suitable for pharmaceutical, agricultural, and fine chemical sectors

Custom Packaging: Flexible packaging options with inert gas protection available

 

 


Product Detail

Product Tags

Product introduction:

4-Chloroacetophenone (CAS Number 99-91-2), also known as p-Chloroacetophenone or 1-(4-Chlorophenyl)ethanone, is a highly functional aromatic ketone that appears as a colorless transparent liquid or white crystalline solid. Manufactured with strict purity control, this product is available at a minimum purity of 99.0% and contains ≤0.20% moisture, making it ideal for applications requiring high chemical precision and consistency.

Due to its robust aromatic structure and functional ketone group, 4-Chloroacetophenone is widely used as an intermediate in pharmaceuticals, agrochemicals, dyes, and research chemicals. It is also recognized for its role in the production of chemical irritants and tear gas under controlled regulations.

Product Specifications

Parameter Value
Product Name 4-Chloroacetophenone
CAS Number 99-91-2
Synonyms p-Chloroacetophenone, 1-(4-Chlorophenyl)ethanone
Molecular Formula C8H7ClO
Molecular Weight 154.59 g/mol
Appearance Colorless transparent liquid or white solid
Purity (by GC) ≥99.0%
Moisture Content ≤0.20%
Melting Point 38–40°C
Boiling Point 245–248°C
Flash Point >110°C
Density (25°C) 1.20 g/cm³
Storage Cool, dry, well-ventilated place, sealed container
HS Code 29143990
Brand Epoch

Applications

4-Chloroacetophenone has broad industrial and laboratory uses, including but not limited to:

1. Pharmaceutical Intermediate

 Precursor for active pharmaceutical ingredients (APIs)

 Used in the synthesis of anti-inflammatory, analgesic, and CNS-targeting drugs

 2. Agrochemical Industry

 Intermediate for herbicides, fungicides, and pesticides

 Offers structural advantages in designing halogenated agrochemicals

 3. Chemical Research & Fine Chemicals

 Serves as a model compound in organic reaction mechanism studies

 Used in preparation of fine chemicals and specialty reagents

 4. Dye & Pigment Manufacturing

 Base compound in the synthesis of complex aromatic dyes

Used in colorants requiring halogenated aromatic building blocks

 5. Controlled Use in Riot Control Agents

 Historically used as an active ingredient in tear gas formulations

 


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