4-Fluoroacetophenone 403-42-9 | High-Purity Colorless Liquid ≥99.5 %

4-Fluoroacetophenone 403-42-9 | High-Purity Colorless Liquid ≥99.5 % Featured Image
  • 4-Fluoroacetophenone 403-42-9 | High-Purity Colorless Liquid ≥99.5 %

Short Description:

4-Fluoroacetophenone (CAS: 403-42-9) is a versatile fluorinated aromatic ketone widely employed as a building block in pharmaceuticals, agrochemicals and advanced materials. Our premium grade appears as a colorless, transparent liquid with exceptionally low moisture content (≤0.20 %) and minimum assay of 99.50 %. The combination of high purity, consistent quality and prompt global logistics makes this product the first choice for R&D teams and scale-up manufacturers alike.

High Purity (≥99.5%)
Ensures minimal by-products and higher reaction yield in downstream synthesis.

Low Moisture (≤0.20%)
Improves shelf life and prevents hydrolytic degradation during storage or reaction.

Stable Physical Properties
Excellent stability under standard storage conditions; no crystallization or discoloration.

Customizable Packaging
Available in bulk or customized volumes to match your supply chain needs.

Technical Support Available

Backed by our technical team for consultation on product use and handling.


Product Detail

Product Tags

Product introduction:

4-Fluoroacetophenone (CAS Number: 403-42-9) is a high-purity, colorless, transparent liquid widely used in the synthesis of pharmaceutical intermediates, agrochemicals, dyes, and specialty chemicals. With a purity of ≥99.50% and moisture content of ≤0.20%, our product guarantees stable quality, reliable performance, and exceptional compatibility with demanding industrial applications.

As a key fluorinated aromatic ketone, 4-Fluoroacetophenone exhibits excellent chemical reactivity and high thermal stability, making it ideal for a variety of fine chemical processes. Our material is manufactured under strict quality control systems, ensuring consistency and compliance with international standards.

Item Specification
Product Name 4-Fluoroacetophenone
CAS Number 403-42-9
Molecular Formula C8H7FO
Molecular Weight 138.14 g/mol
Appearance Colorless transparent liquid
Purity (GC) ≥99.50%
Moisture Content (KF) ≤0.20%
Boiling Point 198–200 °C
Flash Point 86 °C
Density (25°C) 1.13 g/cm³
Refractive Index (n20/D) 1.520–1.524
Packaging 25kg drum or customized
Brand  Epoch

ＣＯＡ

Specification Standard Test Method Typical Result
Appearance Colorless transparent liquid Visual Pass
Purity (GC) ≥99.50 % GC/FID 99.8 %
Moisture ≤0.20 % Karl-Fischer 0.12 %
Fluoride Content 12.6 ± 0.2 % ISE 12.55 %
Refractive Index (20 °C) 1.508 – 1.512 ASTM D1218 1.510
Shelf Life 24 months under nitrogen — —
Documentation COA, MSDS, GHS label — Supplied

Applications of 4-Fluoroacetophenone

4-Fluoroacetophenone is highly versatile and widely utilized in multiple industries. Below are the primary application areas:

Pharmaceutical Intermediates

Serves as a building block for fluoroaromatic compounds.

 Involved in synthesis of anti-inflammatory, analgesic, and CNS-active agents.

 Frequently used in medicinal chemistry for structure-activity relationship (SAR) optimization.

  Agrochemical Industry

 Used in the development of fluorinated herbicides and insecticides.

 Enhances bioavailability and stability of active ingredients.

  Organic Synthesis

 Reagent in Friedel-Crafts acylation reactions.

 Key intermediate in the synthesis of more complex fluorinated compounds.

 Compatible with Grignard reagents and other nucleophilic addition reactions.

 Perfume and Fragrance

 Its subtle aromatic ketone character makes it suitable as a blending agent in fragrance intermediates.

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