4-Phenylacetophenone (CAS 92-91-1) – Premium Aromatic Ketone for Advanced Organic Synthesis

Short Description:

4-Phenylacetophenone, also catalogued as 4-Acetylbiphenyl or 1-(4-Phenylphenyl)ethanone, is a high-value aromatic ketone that serves as a critical building block in the manufacture of APIs, advanced materials and specialty agrochemicals. Our plant-grade product is supplied as a free-flowing white to light yellow powder with ≥99.0 % GC purity and a maximum loss on drying of 0.50 %. Every batch is double-tested and released under ISO 9001 and GMP-compliant protocols to guarantee lot-to-lot reproducibility.

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Product introduction

4-Phenylacetophenone (CAS No. 92-91-1), also known as 1,4-Diphenyl-2-propanone, is a highly stable and versatile aromatic ketone used across pharmaceutical, fragrance, polymer, and fine chemical industries. This compound is typically supplied as a white to light yellow crystalline powder with a purity of 99% min and loss on drying ≤0.50%, making it ideal for demanding applications where product consistency and quality are critical.

With its symmetrical molecular structure and excellent chemical stability, 4-Phenylacetophenone serves as an important building block for complex organic synthesis, especially in the production of pharmaceutical intermediates and performance materials.

Item	Specification
Product Name	4-Phenylacetophenone
CAS Number	92-91-1
Synonyms	1,4-Diphenyl-2-propanone, Benzyl Phenyl Ketone
Molecular Formula	C15H14O
Molecular Weight	210.27 g/mol
Appearance	White to light yellow crystalline powder
Purity (GC)	≥99.0%
Loss on Drying	≤0.50%
Melting Point	60–63 °C
Boiling Point	350 °C (decomposes)
Solubility	Soluble in ethanol, acetone, ether
Packaging	1kg, 5kg, 25kg fiber drum or customized
Brand	Epoch

COA

Parameter	Specification	Test Method
CAS Number	92-91-1	N/A
Chemical Formula	C₁₄H₁₂O	Elemental Analysis
Molecular Weight	196.24 g mol⁻¹	Calculated
Appearance	White to light yellow powder	Visual
Purity (GC)	≥99.0 %	Internal GC-FID
Loss on Drying	≤0.50 %	Karl Fischer
Melting Point	118-123 °C	USP <741>
Residue on Ignition	≤0.10 %	USP <281>
Heavy Metals (as Pb)	≤10 ppm	ICP-MS

Applications of 4-Phenylacetophenone

4-Phenylacetophenone is a highly functional intermediate used in multiple sectors, thanks to its ability to undergo various reactions like condensation, halogenation, and Grignard additions.

Pharmaceutical Industry

Acts as a core intermediate in the synthesis of antipsychotic, anti-inflammatory, and anticancer drug candidates.

Ideal for generating α,β-unsaturated ketones and related pharmacophores.

Frequently used in heterocyclic and benzylated compound synthesis.

Fragrance and Cosmetic Chemistry

Contributes musky, woody notes in fragrance formulations.

Precursor for producing aromatic ingredients with good fixative properties.

Polymer and Resin Manufacturing

Serves as a building block in high-performance polyaromatic compounds.

Adds rigidity and thermal resistance to specialty resin systems.

Academic and Industrial R&D

Widely used in research labs for developing new organic methodologies and material structures.